Histopathology Reporting by Unknown
Author:Unknown
Language: eng
Format: epub
ISBN: 9783030278281
Publisher: Springer International Publishing
S100 protein, HMB45, SOX10 and melanA (MART1). Used in combination as other tumours can show positivity for these individual markers and conversely melanoma may not demonstrate panexpression. HMB45 may diminish in intensity in the dermis in benign lesions but is not a reliable single discriminator with respect to benign versus malignant: cyclinD1 may also show a similar staining pattern. S100 stains, amongst other things, cutaneous dendritic cells which may result in overestimation of melanocyte number. A non-brown immunostain can be applied in very pigmented lesions.
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